The Significance of Blood Eosinophilia in Atopic Dermatitis

Abstract

Background: Atopic dermatitis (AD) is chronic relapsing, pruritic, inflammatory skin disease. Itusually accompanies other atopic problems like asthma and allergic rhinitis. Eosinophil plays a rolein patients with AD.Objectives: To assess blood eosinophils in patients with AD and to evaluate the factors that areaffecting the blood eosinophilia.Materials and methods: This prospective study was conducted at Hit General Hospital in theperiod from October 2018-October 2019. The age, gender, and personal or family history of asthmaor allergic rhinitis of the patients with AD were recorded. The severity of the disease was assessedby the SCORAD score. The total number of eosinophil was measured for each subject. The datawere analyzed using SPSS version 22.Results: Out of 70 patients with AD, 38 (54.3%) were females, and 32 (45.7%) males. The age ofthe patients ranged from 8 months to 30 years (mean 7.59±7.40). The highest age group affectedwas 2-12 years 40 (57.1%). The SCORAD score ranged from 6-80 (mean 24.19±17.59). Themajority of our patients with mild course 50 (71.1%). The majority of the cases were without ahistory of asthma (n=53,75.7%), and around 50% without allergic rhinitis. The range of eosinophilcount was 42-3360 (mean 636.44±491.37). The majority of the subjects (n=53,75.7%) with mildeosinophilia (500-1500/ mm3). The age, gender, and patients with a history of allergic rhinitis orasthma had no significant effect on the number of eosinophils (P-Value >0.05). While, there wasa high statistically significant difference between the eosinophils count, and the severity of AD(P-Value=0.000).Conclusion: From these findings we concluded that blood eosinophilia is a relatively commonlaboratory finding of AD. Blood eosinophilia was influenced by the severity of AD.