Abstract
A controlled trial of a single oral dose of 400 mg. Micoren against placebo in a short-term study is reported. All five patients with “silent” chests showed significant increases in minute-ventilation. Three out of five patients with “wheezy” chests responded favourably. Mean increases in minute-ventilation of up to 24 per cent. were noted and were due to increases in both tidal volume and respiratory rate. The effect was at a maximum after 90 to 120 minutes. Side-effects were few. It was noted that subjective assessment of effect was unreliable. The clinical implications of the findings are discussed.
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