Abstract
(1) Background: Microorganisms originating from the microflora of the oral cavity are the main cause of the inflammatory diseases of the dental pulp and periapical periodontium, as well as the failure of endodontic treatment. The subsequent root canal treatment is not able to remove all the pathogens, and a small number of viable bacteria remain in the dentine tubules, which must be sealed by endodontic sealers. These sealers should have at least a bacteriostatic effect to prevent the remaining bacteria from reproducing. The aim of this study is to compare the short-term antibacterial activity of three endodontic sealers based on poly-epoxy resin, zinc oxide-eugenol and calcium silicate with a calcium hydroxide-based sealer. Calcium hydroxide is used as temporary intracanal medicament and, thus, should show significant antibacterial activity. (2) Methods: A total of 25 bovine dentine samples infected with Enterococcus faecalis were used in this study. After the sealer placement and a 24 h incubation period, the root canal walls were scraped, and the suspension of dentine fillings was used for a semi-quantitative evaluation of microbial growth. (3) Results: The poly-epoxide resin-based sealer ADSeal™ showed significant antibacterial properties. (4) Conclusions: The highest antibacterial activity was shown in poly-epoxide resin-based sealer group, followed by the zinc oxide-eugenol-based sealer and calcium silicate-based sealer.
Highlights
Introduction iationsMicroorganisms and the products of their metabolism play a significant role in the development of inflammatory diseases of the dental pulp and periapical periodontium [1], and they are closely related with the failure of endodontic treatment [2,3] as well
The analysis of variance (ANOVA) did not prove that there were any statistically significant differences between the mean log CFU values depending on the type of sealer, p = 0.179
A statistical analysis of the results has shown no statistically significant differences between the antibacterial activity of the tested sealers and the negative control group
Summary
Introduction iationsMicroorganisms and the products of their metabolism play a significant role in the development of inflammatory diseases of the dental pulp and periapical periodontium [1], and they are closely related with the failure of endodontic treatment [2,3] as well. A different spectrum of microorganisms is present in cases of dental pulp inflammation and in cases of periapical periodontium inflammation, as well as in cases of primary and secondary root canal infection [5]. What all these inflammatory processes have in common is that they are mainly caused by anaerobic microorganisms [4,5]. The treatment of these inflammatory diseases relies on the mechanical and chemical removal of the microbes from the root canal system [6]. The mechanical enlargement of the root canal removes a significant fraction of the microorganisms, it does not ensure the sterility of the root canal system
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