Abstract

While proton density/T2-weighted (PD/T2) MR images are exquisitely sensitive to pathology in brain tissue and play a key role in clinical applications of MRI to multiple sclerosis (MS), they are notoriously non-specific for particular brain pathologies. Moreover, the subtle tissue changes which occur in normal-appearing white matter (NAWM) in MS are not visible on PD/T2 images. However, measurements of T2 relaxation have the potential to provide more specific information about MS tissue pathology, both in lesions and in NAWM.

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