Abstract
The short synacthen test is useful in assessing recovery of adrenal function in patients with central adrenal insufficiency.
Highlights
In the pituitary disease group of patients with secondary Adrenal insufficiency (AI) (SAI), 57% of patients with nonfunctioning pituitary tumors and 44% of patients who underwent pituitary surgery subsequently passed the short synacthen test (SST)
It is important to make the distinction between patients with SAI and tertiary AI (TAI) in this study as the potential for recovery of adrenal function are significantly different in each group but overall across the entire cohort of 886 patients, 37% of patients who initially failed an SST eventually went on to subsequently pass an SST
Untreated or unrecognized AI confers the risk of adrenal crisis and increased morbidity and mortality, it has become
Summary
In the pituitary disease group of patients with SAI, 57% of patients with nonfunctioning pituitary tumors and 44% of patients who underwent pituitary surgery subsequently passed the SST. The study by Pofi et al [9] is a useful addition to the literature reporting results of synacthen testing from a large retrospectively studied cohort of patients with central AI, comprising both SAI (n = 776) and TAI (n = 110), from three academic endocrine centers.
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