Abstract
THE development of acquired resistance to facultative intracellular parasites such as Listeria monocytogenes involves two cytologically distinct but functionally related events: the formation of immunologically committed lymphoid cells and activation of the infected animal's macrophages1. The committed lymphoid cells can immunize adoptively by enhancing macrophage activity in normal recipients. Their strong inhibition by heterologous antilymphocyte globulin2, their ability to pass through cotton that retains preformed macrophages and their presence in the spleens and thoracic duct lymph of Listeria-immune mice3 suggest that they are lymphocytes. Our experiments with the rat complement and extend these observations by showing that Listeria-committed cells belong to a class of lymphocytes that has a rapid turnover rate and a short circulating life span.
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