Abstract
Circular dichroism (CD) has seen three decades of use in the study of the s sheet ⇌ coil transition in polypeptides (Sarkar and Doty, 1966; Townend et al.,1966). The focus here will be on the application of CD to the s sheet ⇌ coil transition in three prototypical systems in which the transition is induced in a homopolypeptide: poly(l-lysine) [poly (Lys)], poly(l-tyrosine) [poly(Tyr)], and poly(S-carboxymethyl-l-cysteine) [poly(CM-cys)].
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