Abstract
BackgroundThe shape of the glucose response curve during an oral glucose tolerance test (OGTT) can predict β-cell function and insulin resistance. However, there have been few studies conducted on Chinese people. Thus, we aimed to verify the usefulness of the glucose response curve in a large Chinese population.MethodsA total of 9059 OGTT (3-h tests) were categorized into either a monophasic or a multiphasic group based on the shape of the glucose response. Homeostasis model assessments of fasting insulin resistance, the Matsuda Index, the insulinogenic index, and the disposition index were assessed by plasma glucose and serum insulin concentration obtained at fasting or during an OGTT.ResultsThe shape of the OGTT glucose response curve was monophasic in 87.3% and multiphasic in 12.7% of participants. Individuals in the multiphasic group were younger compared to those in the monophasic group (38.6 ± 13.6 vs. 35.4 ± 13.5, P < 0.001). Individuals in the monophasic group had significantly higher fasting plasma glucose (FPG 5.6 ± 13.5 vs. 5.2 ± 0.6, P < 0.001), fasting insulin (FINS 14.8 ± 8.7 vs. 13.5 ± 7.9, P < 0.01), and homeostasis model assessment of insulin resistance (HOMA-IR 3.8 ± 2.6 vs. 3.1 ± 2.0, P < 0.001) and impaired β-cell function (disposition index 12.7 ± 14.1 vs. 16.6 ± 17.8, P < 0.001) compared to those in the multiphasic group.ConclusionThe monophasic OGTT glucose response curve could reflect impaired β-cell function in a large Chinese population.
Highlights
The shape of the glucose response curve during an oral glucose tolerance test (OGTT) can predict βcell function and insulin resistance
Baseline characteristics according to glucose curve shapes A total of 9059 OGTTs in 8391 study individuals were included in the final analysis (Fig. 1)
Cross-sectional studies in youths [6,7,8,9,10,11,12,13] and adults [11,12,13, 23] showed that the shape of the OGTT glucose response curve could indicate insulin sensitivity and βcell function, as well as differentiate type 2 diabetes risk
Summary
The shape of the glucose response curve during an oral glucose tolerance test (OGTT) can predict βcell function and insulin resistance. It is widely accepted that the gold standard method for evaluating insulin action is hyperinsulinemic-euglycemic clamp [4]. Because this method is invasive, complicated, and expensive, its. The scale of these studies was generally small, with a maximum of hundreds of subjects included, and only one study was conducted in an Asian population [11]. These studies mainly focused on people without diabetes. Few studies reported the dynamic change of glucose response curves and their relationship with baseline β-cell function and insulin sensitivity
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