The sex related effects of intermittent hypobaric hypoxia on the oxidized modification of proteins in the gingival tissues in immature rats under conditions of changed photoperiod

Abstract

It is shown in experiments that intermittent hypoxia (equivalent to the altitude 4000 meters, 2 hours per day for 14 days) changes the capacity of the oxidized modification of proteins (OMP) in the gingival tissues of immature albino rats. The result of hypoxic effects depends on the sex of animals: in males it causes a decrease of proteins peroxidation intensity both of basic and neutral nature; in females – only a tendency to decrease of the basic OMP.Functional state of the pineal gland changed by experimental conditions (14 days of illumination – “physiological pinealectomy”, or 14 days of darkness – stimulation of the pineal gland) influenced the effects of hypoxia on the OMP in the gingival tissues. The darkness heightens the decreasing effects of hypoxia on the capacity of OMP in the gingival, which is more pronounced in male rats.Our results suggest that by an application of combination of intermittent hypobaric hypoxia and the darkness it is possibleto prevent the process of accumulation of OMP in the gingival tissues.