Abstract
Attacks Does Not Correlate with Severity of Asthma Induced During Oral ASA Challenges A. N. Williams, R. A. Simon, K. M. Woessner, D. D. Stevenson; Scripps Clinic, San Diego, CA. RATIONALE: Historical aspirin (ASA) or nonsteroidal antiinflammatory drug (NSAID)-induced reactions might provide predictive information about the severity of reactions in patients with aspirin exacerbated respiratory disease (AERD) undergoing oral ASA challenges (OAC). METHODS: The provoking doses, treatments, and treatment settings of the historical ASA/NSAID-induced asthma attacks was obtained from 210 consecutive patients with suspected AERD referred for OAC and ASA desensitization. RESULTS: Of 210 subjects, 147 (70%) reported seeking acute medical care for their historical ASA/NSAID-induced asthma attacks. Of these 147, 101 (69%) were treated in ERs and released and 46 (31%) required hospitalization. During OAC in these 147 subjects, 37 (25%) had a >20% decline and 14 (10%) had a >30% decline in FEV1 values. Of the 46 patients previously hospitalized for ASA/NSAID-induced asthma attacks, 15 (33%) had a >20% decline and 6 (13%) had a >30% decline in FEV1 during OAC. By contrast, of the 63 patients who treated their prior ASA/NSAID-induced reactions at home, 10 (16%) had a >20% decline and 5 (8%) had a >30% decline in FEV1 during OAC (p value NS for both). The average provoking doses of ASA were 550 mg for the historical reaction and 62 mg during OAC. CONCLUSIONS: The severity of the historical ASA/NSAID-induced asthma attack was not helpful in predicting asthma severity during OAC. Even though 70% of patients sought acute medical care for asthma attacks provoked by therapeutic doses of ASA/NSAID, a minority had clinically significant asthma during low-dose OAC. These data provide further reassurance regarding the safety of outpatient ASA desensitization. Funding: General Clinical Research Center, Scripps Clinic
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
