Abstract
Several factors affect MHV infection in mice (Table 1). They can be classified into two groups, viral factors and host factors. Although JHMV induces a fatal encephalitis in mice after intracerebral infection, it does a mild hepatitis when it is inoculated intraperitoneally. On the other hand, host genetic factor is a critical determinant. Among MHV researchers, it is well known that SJL mice are relatively resistant to intracerebral infection with JHMV (Stohlman & Frelinger 1978). In addition, the immune system is one of the key players that determine MHV infection in mice.KeywordsViral TiterPrimary HepatocyteAcute Hepatic FailureMouse Hepatitis VirusHost Genetic FactorThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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