The severity and risk factors for mortality in immunocompromised adult patients hospitalized with influenza-related pneumonia

Liang Chen,Xiudi Han,Yanli Li,Chunxiao Zhang,Xiqian Xing

doi:10.1186/s12941-021-00462-7

Abstract

ObjectiveTo explore disease severity and risk factors for 30-day mortality of adult immunocompromised (IC) patients hospitalized with influenza-related pneumonia (Flu-p).MethodA total of 122 IC and 1191 immunocompetent patients hospitalized with Flu-p from January 2012 to December 2018 were recruited retrospectively from five teaching hospitals in China.ResultsAfter controlling for confounders, multivariate logistic regression analysis showed that immunosuppression was associated with increased risks for invasive ventilation [odds ratio: (OR) 2.475, 95% confidence interval (CI): 1.511–4.053, p < 0.001], admittance to the intensive care unit (OR: 3.247, 95% CI 2.064–5.106, p < 0.001), and 30-day mortality (OR: 3.206, 95% CI 1.926–5.335, p < 0.001) in patients with Flu-p. Another multivariate logistic regression model revealed that baseline lymphocyte counts (OR: 0.993, 95% CI 0.990–0.996, p < 0.001), coinfection (OR: 5.450, 95% CI 1.638–18.167, p = 0.006), early neuraminidase inhibitor therapy (OR 0.401, 95% CI 0.127–0.878, p = 0.001), and systemic corticosteroid use at admission (OR: 6.414, 95% CI 1.348–30.512, p = 0.020) were independently related to 30-day mortality in IC patients with Flu-p. Based on analysis of the receiver operating characteristic curve (ROC), the optimal cutoff for lymphocyte counts was 0.6 × 109/L [area under the ROC (AUROC) = 0.824, 95% CI 0.744—0.887], sensitivity: 97.8%, specificity: 73.7%].ConclusionsIC conditions are associated with more severe outcomes in patients with Flu-p. The predictors for mortality that we identified may be valuable for the management of Flu-p among IC patients.

Highlights

Influenza is a common viral respiratory disease that affects between 5 and 10% of the world’s population each year, resulting in roughly 3–5 million severe infections and 290,000–650,000 annual deaths [1, 2]
After controlling for confounders, multivariate logistic regression analysis showed that immunosuppression was associated with increased risks for invasive ventilation [odds ratio: (OR) 2.475, 95% confidence interval (CI): 1.511– 4.053, p < 0.001], admittance to the intensive care unit (OR: 3.247, 95% CI 2.064–5.106, p < 0.001), and 30-day mortality (OR: 3.206, 95% CI 1.926–5.335, p < 0.001) in patients with Influenza-related pneumonia (Flu-p)
Another multivariate logistic regression model revealed that baseline lymphocyte counts (OR: 0.993, 95% CI 0.990–0.996, p < 0.001), coinfection (OR: 5.450, 95% CI 1.638–18.167, p = 0.006), early neuraminidase inhibitor therapy, and systemic corticosteroid use at admission (OR: 6.414, 95% CI 1.348–30.512, p = 0.020) were independently related to 30-day mortality in IC patients with Flu-p

Summary

Introduction

Influenza is a common viral respiratory disease that affects between 5 and 10% of the world’s population each year, resulting in roughly 3–5 million severe infections and 290,000–650,000 annual deaths [1, 2]. Influenzarelated pneumonia (Flu-p) is a severe form of influenza infection associated with over 50% of influenza-related hospitalizations [3, 4]. In recent years, immunocompromised (IC) status has become increasingly recognized as frequent comorbidity of influenza [5]. Observational studies have shown that the influenza vaccine is less effective in IC populations [6, 7]. Together with decreased host defenses, IC individuals have increased susceptibility to influenza virus infection, and have a greater risk of severe outcomes [8, 9].

Methods

Results

Conclusion