The serum uric acid is associated with metabolic risk factors for cardiovascular disease in the Uygur population

Abstract

Objective: The prevalence of hyperuricemia was low in Uygurs who have high prevalence of cardiovascular risk factors such as hypertension, overweight/obesity, dyslipidemia, hyperglycemia and insulin resistance (IR). The study sought to investigate the relationships between serum uric acid (UA) and these risk factors in Uygurs. Methods: A cross-sectional study was conducted in Uygurs (859 males, 1268 females) aged from 20 to 70 years. The demographic data, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), fasting and postprandial blood were obtained and biological measurements were determined. Results: The mean of BMI, SBP, DBP, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides, fasting blood glucose, fasting insulin and HOMA-IR and the prevalence of hypertension, IR, hyperglycemia, overweight/obesity, hypercholesteremia, hyper-LDL-c and hypertriglyceridemia increased with UA but the prevalence of hypo-HDL-c decreased (P<0.05). Logistic regression analysis showed that the odds ratios for IR, overweight/obesity, hypercholesteremia, hyper-LDL-c and hypertriglyceridemia against the lowest UA group increased but decreased for Hypo-HDL-c (P<0.05). The UA in hypo-HDL-c group was lower than that of controls; the prevalence of Hypo-HDL-c in hyperuricemia subjects was lower than those with normal UA (P<0.05). But the opposite results were observed between overweight/obesity, hyperglycemia, IR, hypercholesteremia, hypertriglyceridemia and hyper-LDL-c and correspondence controls, respectively (P<0.05). Conclusions: In Uygur, elevated UA is associated with overweight/obesity, hypercholesteremia, hyper-LDL-c, hypertriglyceridemia, hyperglycemia and IR. The HDL-c level significantly increases with UA, while the prevalence of hypo-HDL-c decreases. Further studies are needed to clarify why UA is positively correlated to HDL-c.