Abstract
The effects of a probiotic acidified milk product on the blood serum metabolite profile of patients suffering from Irritable Bowel Syndrome (IBS) compared to a non-probiotic acidified milk product was investigated using 1H NMR metabonomics. For eight weeks, IBS patients consumed 0.4 L per day of a probiotic fermented milk product or non-probiotic acidified milk. Both diets resulted in elevated levels of blood serum L-lactate and 3-hydroxybutyrate. Our results showed identical effects of acidified milk consumption independent of probiotic addition. A similar result was previously obtained in a questionnaire-based evaluation of symptom relief. A specific probiotic effect is thus absent both in the patient subjective symptom evaluations and at the blood serum metabolite level. However, there was no correspondence between symptom relief and metabolite response on the patient level.
Highlights
Irritable Bowel Syndrome (IBS) is a very common gastrointestinal disorder associated with abdominal pain connected with defecation [1]
As a secondary investigation within a project where blood serum samples from IBS patients enrolled in a large controlled double-blind diet intervention study [10] were collected, the aim of the present study was to investigate the influence of the consumption of acidified milk products with probiotics on the blood serum metabolite composition
The probiotic acidified milk product (Cultura©, Arla Foods amba, Denmark) was produced by fermentation of homogenized, high-pasteurized, low-fat (1.5%) milk by the use of two fermentation starter cultures, Lactobacillus delbruckeii ssp. bulgaricus and Streptococcus thermophilus and the inclusion of three probiotic strains, Lactobacillus paracasei F19, Lactobacillus acidophilus LA-5 and Bifidobacterium lactis BB-12, at concentrations of 5 × 107 CFU/mL
Summary
Irritable Bowel Syndrome (IBS) is a very common gastrointestinal disorder associated with abdominal pain connected with defecation [1]. Abnormal defecation such as diarrhea and constipation along with distension are major symptoms, which do not coincide with demonstrable abnormalities [2]. Some patients suffer from severe symptoms that influence the quality of their everyday life such as travel over short distances and social life [3]. Several studies [4,5,6,7,8,9] have shown that consumption of probiotics has positive effects on gastrointestinal inflammation, thereby conferring benefits to people suffering from. High placebo response is reported based on questionnaires [10,11,12,13], which raises the question of the placebo product or the probiotic delivering matrix having an influence in itself
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