Abstract
The definition of immune Thrombocytopenia (ITP) as a peripheral blood platelet count less than 100 × 109/L instead of the historical criteria of 150 × 109/L renders subjects with platelets between 100 and 150 × 109/L without a diagnosis. Here, we demonstrated that these subjects have enhanced levels of proinflammatory cytokines linked to Th1 and Th17 cell response, and are more frequently carriers of polymorphisms in genes that code cytokines involved in the commitment of Th1 and Th17 immune response, when compared with controls, similarly to that observed in patients with ITP.
Highlights
The definition of immune Thrombocytopenia (ITP) as a peripheral blood platelet count less than 100 × 109/L instead of the historical criteria of 150 × 109/L renders subjects with platelets between 100 and 150 × 109/L without a diagnosis
To the editor According to the International Working Group consensus panel [1], primary Immune Thrombocytopenia (ITP) is defined as a peripheral blood platelet count less than 100 × 109/L in the absence of any obvious cause of thrombocytopenia
The cytokine profile of the studied individuals with platelet count between 100 and 150 × 109/L did not differ from that of ITP patients we have previously studied [6] (IL-17A: 165.0 vs. 169.0 pg/mL, p = 0.55; IL-1β: 2.9 vs. 3.5 pg/mL, p = 0.40; IL-6: 11.9 vs. 14.0 pg/mL, p = 0.32; IL-23: 22.6 vs. 17.7 pg/mL, p = 0.10; IL-2: 18.7 vs. 17.3 pg/mL, p = 0.71; IFN-γ: 23.4 vs. 24.7 pg/mL, p = 0.84; and IL-12p70: 9.0 vs. 7.3 pg/mL, p = 0.46, respectively), but was significantly different from the cytokine profile observed in the healthy blood donors (Figure 1)
Summary
The definition of immune Thrombocytopenia (ITP) as a peripheral blood platelet count less than 100 × 109/L instead of the historical criteria of 150 × 109/L renders subjects with platelets between 100 and 150 × 109/L without a diagnosis. Our group evaluated the serum cytokine profile of 98 patients with chronic ITP (platelet less than 100 × 109/L) [6] attending the University Hospital, Universidade Federal de Minas Gerais, Brazil and demonstrated higher levels of Th17 cell-related
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