Abstract
The diagnostic of hypoxic ischemic encephalopathy of newborns continues to be an actual problem of neonatology. In the course of study healthy children and children with hypoxic ischemic damage of central nervous system were examined. The level of neurotrophic factors in blood was determined using enzyme-linked immunosorbent assay technique. The study established increasing of activity of neuro-specific enolase (NSE), decreasing of content of brain derived neurotrophic growth factor (BDNF) in serum of children of early age. These laboratory parameters are characterized by multi-directional shifts under the given pathology. The receiver operating characteristic analysis permitted to establish diagnostic sensitivity and diagnostic specificity for NSE - 56% and 85% correspondingly and for BDNF - 91% and 46% correspondingly. The level of brain derived neurotrophic growth factor had no significant diagnostic effectiveness. The correlation analysis established no relationships between state of newborn under delivery on Apgar score and level of neurotrophic factors (r<0.3, p>0.05).
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