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Abstract
BackgroundIncreased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease. The purpose of this study is to evaluate the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.MethodsThis is a prospective study involving patients with ankylosing spondylitis, behcet’s disease, presumed sarcoidosis, presumed latent tuberculosis, presumed latent syphilis, and control group. The serum levels of angiotensin converting enzyme and lysozyme were analyzed by enzyme-linked immunosorbent assay. Bonnferoni analysis was used to assess pairwise comparisons between the groups.ResultsThere was a significant increase in serum angiotensin converting enzyme level in patients with presumed sarcoidosis compared to ankylosing spondylitis (p = 0.0001), behcet’s disease (p = 0.0001), presumed latent tuberculosis (p = 0.0001), presumed latent syphilis (p = 0.0001), and control group (p = 0.0001). The increase in serum lysozyme level was significant for patients with presumed sarcoidosis with respect to ankylosing spondylitis (p = 0.0001), behcet’s disease, (p = 0.0001) presumed latent tuberculosis (p = 0.001), presumed latent syphilis (p = 0.033), and control group (p = 0.0001).ConclusionElevated serum angiotensin converting enzyme levels are significant for patients with presumed sarcoidosis compared to ocular involvement of other autoimmune diseases such as behcet’s disease and ankylosing spondylitis, and ocular involvement of infectious diseases such as presumed latent tuberculosis and presumed latent syphilis. However, elevated serum lysozyme level might be also detected in ocular involvement of infectious diseases such as presumed latent tuberculosis and presumed latent syphilis.Trial registrationTrial Registration number: NCT02627209. Date of registration: 12/09/2015.
Highlights
Increased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease
The purpose of this study is to evaluate the significance of differences in serum angiotensin converting enzyme (ACE) and lysozyme levels of patients with ocular involvement of autoimmune diseases such as HLAB27+ ankylosing spondylitis (AS), HLAB51+ behcet’s disease (BD) and presumed sarcoidosis and ocular involvement of infectious diseases such as QuantiFERON(®)-TB Gold+ presumed latent tuberculosis (TB) and presumed latent syphilis compared to control group by using pairwise comparisons between the groups
Presumed latent syphilis was diagnosed on the basis of negative serum venereal disease research laboratory test (VDRL) and rapid plasma reagin test, (RPR) positive serum fluorescent treponemal antibody absorption (FTAABS) and microhemagglutination assay for Treponema pallidum, (MHATP), negative cerebrospinal fluid (CSF) FTAABS, and improvement in level of ocular inflammation after treatment with specific therapy for syphilis [11]
Summary
Increased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease. The purpose of this study is to evaluate the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases. The purpose of this study is to evaluate the significance of differences in serum ACE and lysozyme levels of patients with ocular involvement of autoimmune diseases such as HLAB27+ ankylosing spondylitis (AS), HLAB51+ behcet’s disease (BD) and presumed sarcoidosis and ocular involvement of infectious diseases such as QuantiFERON(®)-TB Gold+ presumed latent tuberculosis (TB) and presumed latent syphilis compared to control group by using pairwise comparisons between the groups
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