Abstract

Objectives: Iron Deficiency Anemia (IDA), a global public health problem may have an inimical effect on thyroid function, especially in women and children. This study was conducted to inspect the correlation between IDA and thyroid disorders in women of Bangladesh.
 Methods: A cross-sectional study was conducted among 452 women of different age groups in particular regions of Bangladesh presenting anemic symptoms and were confirmed anemic after testing of serum hemoglobin levels less than 12 g/dL. To identify the correlation between iron deficiency anemia and thyroid disorders; serum samples were tested quantitatively through standardized methods considering serum iron, total iron-binding capacity (TIBC), ferritin, thyroid-stimulating hormone (TSH), free thyroxin (FT4), and vitamin D levels as parameters. Post clinical diagnosis statistical analysis, graphical presentations of the complex clinical data was generated using advanced computer programming language and bio-analytical tools. 
 Results: A positive correlation between hypothyroidism and IDA in women was discovered in this study as 24.69% of patients with IDA from 0-60 years were found suffering from hypothyroidism simultaneously; with the highest percentage (38.46%) amongst the 31-40 years of age and 26% of iron-deficient females of reproductive age (15-49 years) were suffering from hypothyroidism. Moreover, the association between congenital hypothyroidism and IDA was noticed in 50% of cases above all.
 Conclusion: Hypothyroidism was found quite common among the women of different age groups who were previously reported with acute to chronic anemia symptoms due to iron deficiency.

Highlights

  • Anemia is one of the world’s leading causes of health issues associated with a decline in the total amount of hemoglobin (Hb) than its normal range

  • To identify the correlation between iron deficiency anemia and thyroid disorders few selective tests were conducted such as- serum iron, total iron-binding capacity (TIBC), ferritin, thyroidstimulating hormone (TSH), FT4 and vitamin D

  • The correlation of iron, TIBC, ferritin, TSH, FT4, and vitamin D level in the serum are highly correlated with the thyroid dysfunctions of the anemic patients of all age groups analyzed in the research especially from the age 0 to 60 years women (Fig. 1)

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Summary

Introduction

Anemia is one of the world’s leading causes of health issues associated with a decline in the total amount of hemoglobin (Hb) than its normal range. Thalassemia, Sickle Cell Anemia, etc.), and several inflammatory disorders [6] Among these factors, iron deficiency (ID) has been reported in nearly 50% of all anemia reported worldwide [7]. Anemia due to ID presents with many signs and symptoms including unusual fatigue, impaired immune function, headaches, dyspnea, pale conjunctiva, restless legs, pica, and so on [9,10]. It happens at all phases of the existent cycle of life, though is more predominant in pregnant ladies, children, and teenagers [11]. The daily dietary iron intake is recommended as 18 mg for women of reproductive age instead of 27 mg during pregnancy and 8 mg for men [13]

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