The Separation of Blood Components Using Standing Surface Acoustic Waves (SSAWs) Microfluidic Devices: Analysis and Simulation.

Ahmed Soliman,Taha Taha,Mohamed Eldosoky

doi:10.3390/bioengineering4020028

Ahmed Soliman, Taha Taha + Show 1 more

Open Access

https://doi.org/10.3390/bioengineering4020028

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Abstract

The separation of blood components (WBCs, RBCs, and platelets) is important for medical applications. Recently, standing surface acoustic wave (SSAW) microfluidic devices are used for the separation of particles. In this paper, the design analysis of SSAW microfluidics is presented. Also, the analysis of SSAW force with Rayleigh angle effect and its attenuation in liquid-loaded substrate, viscous drag force, hydrodynamic force, and diffusion force are explained and analyzed. The analyses are provided for selecting the piezoelectric material, width of the main microchannel, working area of SAW, wavelength, minimum input power required for the separation process, and widths of outlet collecting microchannels. The design analysis of SSAW microfluidics is provided for determining the minimum input power required for the separation process with appropriated the displacement contrast of the particles.The analyses are applied for simulation the separation of blood components. The piezoelectric material, width of the main microchannel, working area of SAW, wavelength, and minimum input power required for the separation process are selected as LiNbO3, 120 μm, 1.08 mm2, 300 μm, 371 mW. The results are compared to other published results. The results of these simulations achieve minimum power consumption, less complicated setup, and high collecting efficiency. All simulation programs are built by MATLAB.

Highlights

White blood cells (WBCs), red blood cells (RBCs), and platelets are the components of blood.The separation of blood components is important for medical treatment and diagnosis
The Equation (8) can be modified to express the time required for the particle to migrate from position X1 to position X2 based on standing surface acoustic wave (SSAW) force with Rayleigh angle effect and its attenuation in liquid-loaded substrate, and viscous drag force as following: tSSAW All =
The selection of minimum input power required for the separation process, piezoelectric substrate material, wavelength, width of the main microchannel, widths of outlet collecting microchannels, and working area of surface acoustic wave (SAW) are the main target in our design analysis of SSAW microfluidics for the separation of blood components

Summary

Introduction

White blood cells (WBCs), red blood cells (RBCs), and platelets are the components of blood. The Equation (8) can be modified to express the time required for the particle to migrate from position X1 to position X2 based on SSAW force with Rayleigh angle effect and its attenuation in liquid-loaded substrate, and viscous drag force (tSSAW All ) as following: tSSAW All =. The displacement of particle (dSSAW All ) based on SSAW force with Rayleigh angle effect and its attenuation in liquid-loaded substrate, and viscous drag force can be approximately expressed as following: dSSAW All =. The total displacements of the particles (dTotal ) due to SSAW force with Rayleigh angle effect and its attenuation in liquid-loaded substrate, viscous drag force, hydrodynamic force, and diffusion force can be approximately expressed as following:. The total displacements of the particles (dTotal) due to SSAW force with Rayleigh angle effect and its attenuation in liquid-loaded substrate, viscous drag force, hydrodynamic force, and diffusion force can be approximately expressed as following: dTotal d SSAW All d Hydrodynam ic d Diffusion

Design Analysis

Findings

Conclusions