Abstract
The sensitivity of the opiate receptor, opiates and opioid ligands to ultraviolet light has been examined with the view of using this property to aid in characterizing the receptor. It is demonstrated that the opiate receptor is very sensitive to short wavelength ultraviolet light which causes rapid destruction of opiate binding activity. It is also shown that tritiated and cold opiate ligands are sensitive to light of this wavelength and when the receptor and opiate ligands are irradiated together, irreversible binding occurs. Along with the sensitivity of the receptor system to proteases and phospholipase the photosensitivity will aid in receptor isolation as well as in development of specific photoaffinity labels.
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