Abstract
1. 1. The 1-N-oxidation of adenine in adenosine derivatives, and the corresponding oxidation of cytosine in cytidine derivatives (other bases could not be transformed into the 1-N-oxides under conditions employed), has been applied to polynucleotides. During these reactions characteristic alterations of the ultraviolet spectra of the polynucleotides appeared. After formation of the poly-(A+U) double stranded complex a very strong inhibition of the poly-A oxidation was observed. 2. 2. The oxidation of poly-C-in comparison with poly-A-yielded smaller values for the reaction rate in the starting phase and for the degree of end-oxidation. 3. 3. During oxidation experiments with RNA and DNA, adenine as cytosine units were also oxidized. Only the oxidation degree of the adenine units was studied. Oxidation experiments with DNA showed a dependency of the reaction rate in the starting phase and of the degree of end-oxidation on the condition of the DNA (native or denatured).
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