Abstract
The vertebrate segmentation clock is a molecular oscillator that regulates the periodicity of somite formation. Three signalling pathways have been proposed to underlie the molecular mechanism of the oscillator, namely the Notch, Wnt and Fgf pathways. Characterizing the roles and hierarchy of these three pathways in the oscillator mechanism is currently the focus of intense research. Recent publications report the first identification of a molecular mechanism involved in the regulation of the pace of this oscillator. We review these and other recent findings regarding the interaction between the three pathways in the oscillator mechanism that have significantly expanded our understanding of the segmentation clock.
Highlights
The vertebrate segmentation clock is a molecular oscillator that regulates the periodicity of somite formation
We will discuss our current understanding of the molecular mechanism underlying the generation and tight temporal control of periodicity in the presomitic mesoderm (PSM), which is believed to be regulated by a molecular oscillator termed the segmentation clock
The segmentation clock Due to the requirement for a specific number of somites to form in a given time period it is critical that somite formation is under tight temporal control
Summary
The vertebrate segmentation clock is a molecular oscillator that regulates the periodicity of somite formation. In addition to the oscillation of Hes-related genes, a similar dynamic expression of other Notch pathway components has since been reported in the PSM of all vertebrate species studied [3,26,27,28].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
