The sedative and anticonvulsant activity of some substituted pyrrolidones and piperidones.

Abstract

British Journal of Pharmacology and ChemotherapyVolume 25, Issue 3 p. 790-799 Free Access THE SEDATIVE AND ANTICONVULSANT ACTIVITY OF SOME SUBSTITUTED PYRROLIDONES AND PIPERIDONES B. J. EVERITT, B. J. EVERITT Department of Pharmacology, Smith, Kline & French Laboratories, Welwyn Garden City, Herts. Department of Pharmacology, Riker Laboratories, Tewin Road, Welwyn Garden City.Search for more papers by this authorG. H. HALL, G. H. HALL Department of Pharmacology, Smith, Kline & French Laboratories, Welwyn Garden City, Herts. Tobacco Research Council Laboratories, Otley Road, Harlow Hill, Harrogate.Search for more papers by this authorE. M. TAYLOR, E. M. TAYLOR Department of Pharmacology, Smith, Kline & French Laboratories, Welwyn Garden City, Herts.Search for more papers by this author B. J. EVERITT, B. J. EVERITT Department of Pharmacology, Smith, Kline & French Laboratories, Welwyn Garden City, Herts. Department of Pharmacology, Riker Laboratories, Tewin Road, Welwyn Garden City.Search for more papers by this authorG. H. HALL, G. H. HALL Department of Pharmacology, Smith, Kline & French Laboratories, Welwyn Garden City, Herts. Tobacco Research Council Laboratories, Otley Road, Harlow Hill, Harrogate.Search for more papers by this authorE. M. TAYLOR, E. M. TAYLOR Department of Pharmacology, Smith, Kline & French Laboratories, Welwyn Garden City, Herts.Search for more papers by this author First published: December 1965 https://doi.org/10.1111/j.1476-5381.1965.tb01802.xCitations: 1 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES Branchini, R., Casini, G., Ferappi, M. & Gulinelli, S. (1960). Sugli antipodi ottici della α-fenil-α-etil glutariminide. Farmaco, Ed. Sci., 15, 734– 758. Carvajal, G., Russek, M., Tapia, R. & Massieu, G. (1964). Anticonvulsive action of substances designed as inhibitors of γ-aminobutyric acid-α-ketoglutaric acid transaminase. Biochem. Pharmacol., 13, 1059– 1069. Chen, G. (1962). Techniques for evaluating sedative and anticonvulsant drugs. In Psychosomatic Medicine, ed. Nodine & Meyer, pp. 257– 266. Philadelphia: Lea & Febiger. Chen, G. & Portman, R. (1952). Titration of central-nervous system depression. Arch. Neurol. Psychiat. (Chic.), 68, 498– 505. Dunham, S. & Miya, T. S. (1957). A note on a simple apparatus for detecting neurological deficit in rats and mice. J. Amer. pharm. Ass., sci. Ed., 46, 208– 209. Ferster, C. B. & Skinner, B. F. (1957). Schedules of Reinforcement. New York: Appleton-Century Crofts. Goodman, L. S., Grewal, M. S., Brown, W. C. & Swinyard, E. A. (1952). Comparison of maximal seizures evoked by pentylenetetrazol (metrazol) and electroshock in mice, and their modification by anticonvulsants. J. Pharmacol, exp. Ther., 108, 168– 176. Goodman, L. S., Toman, J. E. P. & Swinyard, E. A. (1946). The anticonvulsant properties of tridione. Amer. J. Med., 1, 213– 228. Kärber, G. (1931). Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak., 162, 480– 483. Kleitman, N. (1939). Sleep. Physiol. Rev., 9, 624– 665. Laycock, G. M. & Shulman, A. (1963). Partial agonists in the central nervous system. Nature (Lond.), 200, 849– 851. Litchfield, J. T. & Wilcoxon, F. (1949). A simplified method of evaluating dose-effect experiments J. Pharmacol, exp. Ther., 96, 99– 113. McCance, I. (1964). Studies of potentiation of hexobarbitone infused intravenously. Arch. int. Pharmacodyn., 148, 270– 286. Russek, M. (1964). New drugs may block grand and petit mal. Cited in Med. Wld News, 5, 72. Swinyard, E. A., Brown, W. C. & Goodman, L. S. (1952). Comparative assays of antiepileptic drugs in mice and rats. J. Pharmacol, exp. Ther., 106, 319– 330. Tedeschi, R. E., Tedeschi, D. H., Mucha, A., Cook, L., Mattis, P. A. & Fellows, E. J. (1959). Effects of various centrally acting drugs on fighting behaviour in mice. J. Pharmacol, exp. Ther., 125, 28– 34. Citing Literature Volume25, Issue3December 1965Pages 790-799 ReferencesRelatedInformation