Abstract
Cortisol and corticosterone are quantitatively the most important hormonal steroids secreted by the adrenal cortex in man (Bush & Sandberg, 1953; Bondy & Altrock, 1953). The value of the ratio of the amounts of these two substances secreted by human subjects has been the subject of much controversy. Romanoff, Hudson & Pincus (1953) isolated crystalline cortisol and corticosterone from adrenal venous blood of human subjects in the proportions of 10:1. Sweat (1955) reported ratios of 2:1 and 10:1 for adrenal venous blood of two women with breast cancer, and Hudson & Lombardo (1955) found ratios of 11:1 and 4:1 in two similar cases. Bush & Sandberg, using a rough quantitative paperchromatographic method, found that the lowest ratio of cortisol-like to corticosterone-like substances in peripheral blood was 4:1. Morris & Williams (1953), however, measuring these steroids in peripheral blood by a polarographic method found ratios as low as 1:1 and Sweat
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