The secondary hyperoxaluria in children: the therapeutic potential of prebiotics and probiotics

Abstract

The article presents modern data on the use of probiotic and prebiotic drugs to prevent the formation of secondary hyperoxaluria in children. The authors analyzed the literature data and generalized the available results of original studies on the use of probiotics and prebiotics to prevent the development and to reduce the laboratory manifestations of secondary hyperoxaluria by improving the state of the intestinal microflora involved in the degradation of oxalates. They demonstrated the ability of Oxalobacter formigenes, Lactobacillus spp. и Bifidobacterium spp. bacteria to participate in the metabolism of oxalates, to reduce the excretion of oxalates with the urine, thereby reducing the laboratory manifestations of secondary hyperoxaluria. The article shows the therapeutic correction of the disease by improving the state of the intestinal microflora with both probiotic preparations containing Lactobacillus spp. and Bifidobacterium spp. strains and prebiotic agents. The drugs that normalize the state of the intestinal microflora (probiotics and prebiotics) help to rationalize the management of patients with secondary hyperoxaluria and to reduce the manifestations of secondary hyperoxaluria.