Abstract

The second Annual Meeting of the International Ovarian Cancer Consortium (IOCC) was held in conjunction with the Symposium on Tumor Microenvironment and Therapeutic Resistance at the Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, and USA. A brief welcoming event along with the banquet on Aug 16th was followed by the eight thematic scientific sessions from August 16 to 18, 2015. Forty-three lectures, organized in eight sessions, were discussed in front of an audience of more than hundred attendees. Emphasis was put on oncogene signaling in cancer genesis and progression, new approaches in Precision Medicine and therapy of ovarian cancer, the role of tumor microenvironment in carcinogenesis, and preventive/curative potential of natural products. In this meeting-report, we highlight the findings and the perspectives in cancer biology and therapeutic strategies that emerged during the conference.

Highlights

  • Ovarian cancer remains the leading cause of death from gynaecological malignancies in women, in spite of the progress in drug discovery and improvement in the clinical management of the disease that were made in the last fifty years

  • The International Ovarian Cancer Consortium (IOCC) was founded in 2014 in occasion of its first annual meeting that was held in February 9-11 at the Stephenson Cancer Center (SCC) at the University of Oklahoma Health Sciences Center, Oklahoma City

  • The second meeting of IOCC was held on August 1618, 2015 in conjunction with the third Symposium on Tumor Microenvironment and Therapeutic Resistance

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Summary

INTRODUCTION

Ovarian cancer remains the leading cause of death from gynaecological malignancies in women, in spite of the progress in drug discovery and improvement in the clinical management of the disease that were made in the last fifty years. The International Ovarian Cancer Consortium (IOCC) was founded in 2014 in occasion of its first annual meeting that was held in February 9-11 at the Stephenson Cancer Center (SCC) at the University of Oklahoma Health Sciences Center, Oklahoma City. The scientific program listing the invited speakers and the titles of their lectures delivered at the 1st IOCC meeting is provided at the SCC website. The second meeting of IOCC was held on August 1618, 2015 in conjunction with the third Symposium on Tumor Microenvironment and Therapeutic Resistance. This choice was quite appropriate, given that the cancer aggressiveness reflects changes in the composition of www.impactjournals.com/Genes&Cancer the tumor microenvironment, with stromal cells secreting factors that facilitate cancer progression. We summarize the novelties presented in the lectures and the perspectives emerged from the discussion

Ovarian Carcinogenesis
Chemoresistance and Cancer Targeted Therapy
Role of Tumor Microenvironment in Cancer Progression
Bioinformatic and Xenograft Technology for Personalized Treatments
Chemoprevention with Natural Products
CONCLUSION
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