Abstract
The stromal cell derived factor-1 (SDF-1) rs1801157 gene polymorphism has been implicated in susceptibility to cancer, but the results were inconclusive. The current study was to precisely investigate the association between SDF-1 rs1801157 polymorphism and cancer risk using meta-analysis and the false positive report probability (FPRP) test. All 17,876 participants were included in the study. The meta-analysis results indicated a significant association between the SDF-1 rs1801157 polymorphism and cancer risk. By subgroup analyses, the results detected that the SDF-1 rs1801157 polymorphism was associated with cancer susceptibility among Asians and Caucasians. Additionally, we also found significant associations between the SDF-1 rs1801157 polymorphism and susceptibility to different types of cancer. However, to avoid a “false positive report”, we further investigated the significant associations observed in the present meta-analysis using the FPRP test. Interestingly, the results of the FPRP test indicated that only 4 gene models were truly associated with cancer risk, especially in Asians. Moreover, we confirmed that the SDF-1 rs1801157 gene polymorphism was only associated with lung and urologic cancer risk. In summary, this study suggested that the SDF-1 rs1801157 polymorphism may serve as a risk factor for cancer development among Asians, especially an increased risk of urologic and lung cancers.
Highlights
The stromal cell derived factor-1 (SDF-1) rs1801157 gene polymorphism has been implicated in susceptibility to cancer, but the results were inconclusive
In the overall meta-analysis, the results suggested a significant association between the SDF-1 rs1801157 polymorphism and cancer susceptibility in the recessive model (AA vs. AG + GG, OR: 1.28, 95% CI: 1.11–1.47, P = 0.001), a co-dominant model (AA vs. GG, OR: 1.43, 95% CI: 1.24–1.65, P < 0.001)
Previous studies have suggested that cancer risk factors include an unhealthy life style, environmental pollution, radiation, infection, and immunity dysfunction[45,46,47]
Summary
The stromal cell derived factor-1 (SDF-1) rs1801157 gene polymorphism has been implicated in susceptibility to cancer, but the results were inconclusive. The current study was to precisely investigate the association between SDF-1 rs1801157 polymorphism and cancer risk using meta-analysis and the false positive report probability (FPRP) test. The meta-analysis results indicated a significant association between the SDF-1 rs1801157 polymorphism and cancer risk. The results of the FPRP test indicated that only 4 gene models were truly associated with cancer risk, especially in Asians. We confirmed that the SDF-1 rs1801157 gene polymorphism was only associated with lung and urologic cancer risk. This study suggested that the SDF-1 rs1801157 polymorphism may serve as a risk factor for cancer development among Asians, especially an increased risk of urologic and lung cancers. One important SDF-1 gene polymorphism named rs1801157 (G801A) involves a guanine to adenine (G→C) substitution at base pair 801 of the 3′-untranslated region of SDF-1 gene[9]
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