The Screening of Epigenetic Regulatory Elements of IGFBP2 and Impact on the Survival of Colonal Cancer

Abstract

IGFBP2 (insulin-like growth factor binding protein 2), is overexpressed in a wide spectrum of cancers, and plays a role through regulating the concentration of IGF and promotes the development of neoplasm. The role of IGFBP2 in cancer is unclear, while in general it is considered to be oncogenic. In addition, IGFBP2 is closely connected with the level and prognosis of neoplasm. Large studies have been contributed to the relationship between IGFBP2 and cancer, but few are in the epigenetic field. In this study, we filtered differentially methylated sites in the cis regulatory region of IGFBP2, and found 25 and 9 sites in high and low expression groups. In the following survival analysis, we found two sites could distinguish the samples of long survival time from the short ones. This study filtered several epigenetic elements that regulate the expression of IGFBP2. They can be considered for the drug targets for regulating the expression of IGFBP2 and improving the therapeutic effect in cancer.