Abstract
Abstract The present study outlines the antioxidant and toxic activity, total phenol, flavonoid and tannin content of Digitalis ferruginea’s extracts in addition to evaluating its proximate parameters and mineral elements. Successive extraction was made using different solvents (ethanol, acetone, water). Total phenol content was determined by the Folin-Ciocalteu’s reagent method and flavonoid was determined by the aluminum chloride colorimetric method. The antioxidant activities were investigated using different assays. The phenolics were determined using HPLC. In addition an evaluation was made of the proximate parameters and mineral elements. The radical scavenging capacities were highest in the water extract. The same extract was effective in total antioxidant activities (β-carotene, 83.75%). The acetone extract demonstrated stronger reducing power and phosphomolybdenum antioxidant activity with 0.52 mg/mL and, 107.43 µg/mg, respectively. The HPLC results determined major phenolics: rutin and ferulic acid. This plant also have rich in polyphenolic content together with toxic activity and possesses nutrients and mineral elements. As well as demonstrating the good antioxidant activity of D. ferruginea this study suggest that the plant could be of particular interest from a practical perspective, as it is a significant source of potential natural antioxidants that can be used for the prevention of a range of diseases.
Highlights
It is widely acknowledged that reactive oxygen species are closely associated with a range of human diseases, including cancer, inflammation and aging
Many researchers are looking for natural antioxidants that are potent but safe, in particular those sourced from medicinal plants (Elmastaş et al, 2006; Moein et al, 2008; Rufino et al, 2010; Santos & Gonçalves, 2016)
Methanol extract from D. ferruginea L. subsp. ferruginea has been investigated for phenolic compounds, antioxidant, antimicrobial and enzyme inhibitory activities (Katanić et al, 2017)
Summary
It is widely acknowledged that reactive oxygen species are closely associated with a range of human diseases, including cancer, inflammation and aging. It is well known note that even within a single method a small difference in solvent polarity may provide different responses, due to the diversity of the chemical nature of these compounds and their often unique distribution within the plant matrix (Antolovich et al, 2000; Turkmen et al, 2006; Sultana et al, 2009) For this reason, the antioxidant efficacy of the resulting extracts is strongly affected, as mentioned above, by a polarity of the solvent and the chemical nature of the isolated compounds (Sultana et al, 2009; Shabir et al, 2011). A significant contribution could be made to medicinal plant
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