Abstract
The science of teratology is discussed from a regulatory point of view. A brief history of this branch of toxicology is presented with emphasis on specific instances of the inadvertent production of birth defects in humans as a result of exposure to exogenous agents. The basic principles of teratology are elucidated as a means of understanding current test protocols and their scientific rationale. A typical, general protocol is given and some of the major shortcomings of such a bioassay are presented. Among these shortcomings are the problems of significance of fetal toxicity and lack of a postnatal component to the teratology test system. The teratogenic and/or fetotoxic potential of selected pesticides are examined with special reference to the bioassay problems alluded to. Pesticides discussed include cacodylic acid, endrin, benomyl, ETU, nitrofen, and mirex. Finally, a brief discussion of a proposed teratology screen using pregnant laboratory animals is presented.
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