Abstract
This review presents selected data on the probiotic strain Bifidobacterium animalis subsp. lactis BB-12® (BB-12®), which is the world’s most documented probiotic Bifidobacterium. It is described in more than 300 scientific publications out of which more than 130 are publications of human clinical studies. The complete genome sequence of BB-12® has been determined and published. BB-12® originates from Chr. Hansen’s collection of dairy cultures and has high stability in foods and as freeze dried powders. Strain characteristics and mechanisms of BB-12® have been established through extensive in vitro testing. BB-12® exhibits excellent gastric acid and bile tolerance; it contains bile salt hydrolase, and has strong mucus adherence properties, all valuable probiotic characteristics. Pathogen inhibition, barrier function enhancement, and immune interactions are mechanisms that all have been demonstrated for BB-12®. BB-12® has proven its beneficial health effect in numerous clinical studies within gastrointestinal health and immune function. Clinical studies have demonstrated survival of BB-12® through the gastrointestinal tract and BB-12® has been shown to support a healthy gastrointestinal microbiota. Furthermore, BB-12® has been shown to improve bowel function, to have a protective effect against diarrhea, and to reduce side effects of antibiotic treatment, such as antibiotic-associated diarrhea. In terms of immune function, clinical studies have shown that BB-12® increases the body’s resistance to common respiratory infections as well as reduces the incidence of acute respiratory tract infections.
Highlights
Ten (39%) of the subjects who received the control formula and three (10%) of those who received the supplemented formula shed rotavirus at some time during the study. These results suggest that supplementation of infant formula with BB-12® and S. thermophilus TH-4® can reduce the incidence of acute diarrhea and rotavirus shedding in children admitted to hospital
These results show that BB-12® and LA-5® can effectively reduce the duration and severity of associated diarrhea (AAD) [33]
In vitro and animal studies have contributed to the understanding of strain characteristics and mechanisms of BB-12®
Summary
The human body consists of approximately 10 trillion cells, each encoding approximately. We are outnumbered by our microbiome—the bacteria living on and in us. The microbiome is made up of more than 500 different species and accounts for around 100 trillion cells encoding 3.3 million different genes. The microbiome plays a major role in human health through intimate interaction with the body. The bacteria living in the intestine—the gastrointestinal microbiota—constitute the largest part of the microbiome. Research on the gastrointestinal microbiota, as well as of probiotics, has increased significantly in the new millennium and the interaction between the gastrointestinal microbiota and probiotics—. Clinical research has shown that probiotics play a role within various health areas, of which the two main research areas are gastrointestinal health and immune function
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