Abstract
The emergence of malaria resistant to one or more classes of anti-malarials constitutes a major problem in chemotherapy of this disease. Hence a study was carried out to monitor the degree of sensitivity of different schizonticidal response to chloroquine sulphate, quinine dihydrochloride and sulfadoxine+pyrimethamine (s/p) combination in malarial patients in Nnewi. From this study, we discovered that pyrimethamine+sulfadoxine has the highest sensitivity to P. falciparim species of malaria and this was closely followed by quinine dihydro-chloride and chloroquine sulphate running a distant third place. The study therefore suggests that pyrimethamine/sulfadoxine should be chosen as a drug of first choice in treatment of p.falciparum specie of malaria parasite in Nnewi Anambra State. Key Words: Chloroquine, Quinine, Sulphadoxine/Pyrimethamine, malarial patient. Journal of Biomedical Investigation Vol.1 2003: 28-32
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