Abstract
A question hotly debated in neuroscience concerns the origins of learning: Does long-term potentiation--the enhancement of synaptic function triggered by strong stimulus--represent the neural basis of learning? In his Perspective, Bliss discusses results reported in the same issue by [ Moser et al .][1] in which the authors have revisited a classic experiment carried out 10 years ago. With strengthened experimental design, Moser et al . used implanted electrodes to saturate the long-term potentiation in rats trained to solve a maze problem. As predicted by the LTP-as-learning hypothesis, the saturated rats did poorly, being unable to learn the maze, in comparison to the control animals. [1]: http://www.sciencemag.org/cgi/content/short/281/5385/2038
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