Abstract

This article describes the Salvador Primary Care Longitudinal Study of Child Development (CohortDICa). The exposed group was defined by confirmation of Congenital Zika Syndrome (CZS) diagnosed through computed tomography, magnetic resonance or transfontanellar ultrasound. A random selection of the 169 exposed children led to a subgroup of 120 children who were paired with children from the Live Birth Information System, according to birthdate, residence in the same street or neighborhood, and gestational age, resulting in 115 subjects in the non-exposed group. Following recruitment and before the participants completed 42 months, three measures were applied to assess cognitive, motor, and language performance, corresponding to three home visits. Social characteristics of the families and children, and the neurocognitive development of the children will be compared across the CZS exposed group (n = 147), the typical children with no exposure to CZS (n = 115) and the STORCH exposed group (Syphilis, Toxoplasma gondii, Rubella, Cytomegalovirus, and Herpes simplex) (n = 20). Primary Health Care (PHC) should include long-term care strategies for the care of children and family members, and might benefit from the research, teaching, and extension activities provided in this study. In the face of the consequences of the Zika virus epidemic, an opportunity arose to intervene in the integrated care of child development within PHC, including, on an equal basis, typical children and those with delays or disabilities in the first six years of life.

Highlights

  • A community prospective cohort study was conducted to assess the effects of the congenital neurological disorders associated with the Zika virus on child development using data from children born between 1 August 2015 and 31 July 2016 in Salvador, Bahia, Brazil, registered on the databases of the Municipal Health Department’s Strategic Information Centre for Health Surveillance (CIEVS/SMS) and the Live Birth Information System (SINASC)

  • In order to compare differences in cognitive performance between children exposed to Congenital Zika Syndrome (CZS) and children who were not, we considered an average cognitive performance score of 94.94 (SD 10.14) for children aged under 42 months [15]

  • Health Services and Recruiting the Cohort. This protocol describes a population-based cohort that was established with participants recruited from Salvador’s Municipal Health CIEVS/SMS and SINASC databases at the peak of the CZS epidemic in Salvador, Bahia, Brazil; three child development home assessments were carried out

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Summary

Introduction

In April 2015, a recommendation was made for the surveillance of microcephaly and/or central nervous system (CNS) impairments in newborns associated with Zika virus (ZIKV) infection in Brazil, as a result of the ZIKV epidemic in the country [1]. Detection would support early intervention and support. A lack of public health services with qualified teams, capable of monitoring and caring for children with such severe health problems in a country marked by social inequalities, was an important challenge to their developmental follow-up.

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