Abstract
It was previously shown 1 that individuals receiving full therapeutic doses of salicylate invariably have albumin, leukocytes and casts or cast-like bodies in the urine. This albuminuria is produced in both febrile and afebrile individuals, and is of renal origin. The functional tests (phenolsulphonephthalein excretion in urine and nonprotein nitrogen of the blood) which were applied at the time, gave inconstant results, and the changes in some cases were so small that it was impossible to conclude definitely whether any serious impairment in the functional efficiency of the kidney existed. It is possible that repeated administration of salicylate might cause more definite and marked changes in the kidney, both functionally and morphologically. Moreover, in certain individuals, the albuminuria and other changes are so severe that the presence of a definite nephritis is suggestive. Von Ackeren 2 gave sodium salicylate and salicylic acid per os to five rabbits, and two
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