Abstract
TXA (Tranexamic acid) can be used to reduce blood loss in total joint arthroplasties. Due to the correlation between acute anemia occurring after total joint arthroplasties and postoperative morbidity/mortality rates, many studies were focused on different modalities to minimize blood loss. TXA can be administered by different routes: intravenous, topical, oral or a combination of these. The effective dose and administration technique of TXA is still controversial. Safety of TXA in clinical practice has been debated for a long time. TXA does not increase symptomatic or asymptomatic DVT (Deep vein thrombosis) risk. The safety of TXA is still unclarified in high-risk and comorbid patients. Prospective studies to establish stronger recommendations are necessary.
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