The Safety Evaluation of Some Plants of the Zingibereceae Family

Abstract

: The Zingiberaceae family has long been used by the community as a spice, cosmetic ingredient, spice ingredient, and as an ingredient in traditional medicine. Toxicity testing is also essential as the first step in drug safety parameters before being used as a human drug product. This review article aims to identify and review scientific information from research thatched regarding the safety of the use of plants, especially those from the Zingiberaceae family. A literature study is used as a method in writing this article review. Literature searches were conducted online through search engines such as Google Scholar, Pubmed, and NCBI using the keyword "Zingiberaceae". "Toxicity test" and "Toxicity" followed by each plant's Latin name. The library criteria used are international journals indexed in Scopus Q1 to Q4 and national journals indexed in Sinta S1 to S6 published in the last ten years (2012-2022). A literature search found that 18 plants from the Zingiberaceae family had their toxicity tested acutely, subacutely, and chronically including Alpinia calcarata, Alpinia galanga, Alpinia malaccensis, Amomum compactum Sol. Ex Maton, Boesenbergia rotunda, Curcuma angustifolia. Curcuma caesia, Curcuma longa, Curcuma xanthorriza, Curcuma comosa, Etlingera elatior, Globba pendula, Hedychium spicatum, Kaempferia galanga, Kaempferia rotunda, Zingiber officinales, Zingiber zerumbet, and Zingiber cassumunar are categorized as non-toxic.