Abstract
Background: Uncommonly high rates of pneumonia in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) have been observed during recent years. Inspiratory muscle training (IMT) could reduce pneumonia in patients undergoing coronary artery bypass grafting and other cardiac surgeries. The relationship between IMT and AMI is unknown. Here, we describe the feasibility and potential benefit of IMT in patients at high risk for pneumonia with AMI who have undergone primary PCI.Methods: Our study is a prospective, randomized, controlled, single-center clinical trial. A total of 60 participants will be randomized into an IMT group and control group with 30 participants in each group. Participants in the IMT group will undergo training for 15 min per session, twice a day, from 12 to 24 h after primary PCI, until 30 days post-randomization; usual care will be provided for the control group. The primary endpoint is the change in inspiratory muscle strength, the secondary endpoint included feasibility, pneumonia, major adverse cardiovascular events, length of stay, pulmonary function tests measure, and quality of life.Discussion: Our study is designed to evaluate the feasibility of IMT and its effectiveness in improving inspiratory muscle strength in participants with AMI who have undergone primary PCI.Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT04491760.
Highlights
High rates (2–7%) of pneumonia have been reported in patients with acute myocardial infarction (AMI), increasing the mortality of such patients [1,2,3,4]
Our study is designed to evaluate the feasibility of Inspiratory muscle training (IMT) and its effectiveness in improving inspiratory muscle strength in participants with AMI who have undergone primary percutaneous coronary intervention (PCI)
We will record the clinical adverse events and the satisfaction of these patients and try to determine whether IMT has a potential benefit for decreasing incidence of pneumonia, Major Adverse Cardiovascular Events (MACE) and length of stay (LOS), and determine if IMT could benefit pulmonary function and quality of life
Summary
High rates (2–7%) of pneumonia have been reported in patients with acute myocardial infarction (AMI), increasing the mortality of such patients [1,2,3,4]. Inspiratory muscle training (IMT) could significantly increase MIP and has been considered a feasible method to reduce pneumonia in patients undergoing cardiac surgery including coronary artery bypass grafting [6, 7]. We aim to conduct 30 days of IMT in patients with AMI who are at high risk of pneumonia and have undergone primary percutaneous coronary intervention (PCI), to evaluate the effectiveness and feasibility of IMT in this population. High rates of pneumonia in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) have been observed during recent years. Inspiratory muscle training (IMT) could reduce pneumonia in patients undergoing coronary artery bypass grafting and other cardiac surgeries.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
