Abstract
Tumor necrosis factor superfamily member 4 (TNFSF4), also known as Ox40 ligand (Ox40l), plays an important role in atherosclerosis development. Several studies reported the association between the rs3850641 polymorphism of the TNFSF4 gene and the risk of myocardial infarction (MI). However, the results are inconsistent. In order to explore the relationship between the rs3850641 polymorphism of the TNFSF4 gene and MI, we conducted a case–control study including 454 cases and 512 controls in a Chinese Han population. Genotyping was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The present study found that AA genotype (AA vs. GG: odds ratio (OR) & 95% confidence interval (CI), 2.00(1.04,3.86), P=0.039; AA vs. AG+GG: OR & 95% CI, 1.93(1.00,3.70), P=0.049) or A allele carriers (A vs. G: OR & 95% CI, 1.27(1.00,1.60), P=0.047) of the rs3850641 polymorphism of the TNFSF4 gene increased the risk of MI. In conclusion, this case–control study confirms that the rs3850641 polymorphism of the TNFSF4 gene increases the risk of MI.
Highlights
Coronary heart disease (CHD) is a significant risk factor for mortality, with myocardial infarction (MI) being the most serious consequence of CHD [1]
It was suggested that single nucleotide polymorphisms (SNPs) of the Tumor necrosis factor superfamily number 4 (TNFSF4) gene are associated with MI and CHD severity in humans [9]
These results demonstrated that hypertension, hyperlipidemia, and obesity are important risk factors for the development of MI in the Chinese Han population
Summary
Coronary heart disease (CHD) is a significant risk factor for mortality, with myocardial infarction (MI) being the most serious (and fatal) consequence of CHD [1]. Alcohol intake, diabetes, hypertension, hypercholesterolemia, obesity, physical inactivity, and certain psychosocial factors are known to be risk factors for MI pathogenesis [3]. Several studies have demonstrated that genetic factors play a critical role on MI development [4,5]. Tumor necrosis factor superfamily number 4 (TNFSF4), known as OX40 ligand (OX40L), is located in human chromosome 1 and encodes a type II glycoprotein. Malarstig et al [8] suggested that TNFSF4 gene polymorphisms are associated with the incident atherothrombosis and venous thromboembolism risk in Caucasians. It was suggested that single nucleotide polymorphisms (SNPs) of the TNFSF4 gene are associated with MI and CHD severity in humans [9]. It is reasonable to hypothesize that the TNFSF4 may be a candidate gene for MI susceptibility
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