Abstract
Microseminoprotein-beta (MSMB) is one of the most abundant proteins in human seminal plasma. The current study was aimed to assess the impact of MSMB rs10993994, rs12770171, rs10994385 variants on prostate cancer (PCa) risk in a sample of Iranian population. This case-control study was executed on 169 pathologically confirmed PCa patients and 182 benign prostatic hyperplasia (BPH). Genotyping was performed by using the PCR-RFLP method. Our findings showed that rs10993994 variant significantly increased the risk of PCa in codominant (OR=1.64, 95%CI=1.04–2.59, P=0.038, CT vs TT) and overdominant (OR=1.64, 95%CI=1.03–2.43, P=0.039, TC vs TT+CC) models. However, no significant association was observed among rs10994385 G>C and rs12770171 C>T polymorphisms and PCa risk.In summary, the findings showed that MSMB rs10993994 polymorphism increased the risk of PCa in an Iranian population. To verify our findings, well-designed studies with larger sample sizes and representing various ethnicities are needed.
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