Abstract
The cytochrome P450 steroid hydroxylases are expressed in a tissue-specific and developmentally regulated fashion (Miller 1988). Over the past several years, a major goal at our laboratory has been to define the molecular mechanisms that determine this regulation. As detailed below, each of these genes contains at least one copy of a shared regulatory element that interacts with a cell-selective, orphan nuclear receptor, steroidogenic factor 1 (SF-1). Recent studies have defined key roles of SF-1 in diverse endocrine processes that include adrenal and gonadal development, gonadotrope function, and development of the ventromedial hypothalamic nucleus. These studies collectively provide novel insights into mechanisms of endocrine development and reproductive function.
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