The Roles of Procalcitonin, C-Reactive Protein and Erythrocyte Sedimentation Rate in Predicting Bacteremia

Faqi Mk,Elmusharaf K,Al-Qahtani M

doi:10.15744/2394-6512.1.206

Abstract

1Orthopedic Resident, Department of Orthopedics, Royal Medical Services, Bahrain Defence Force Hospital, Riffa, Bahrain 2Clinic Microbiologist, Head of Microbiology, Pathology and Laboratory Medicine Department, Royal Medical Services, Bahrain Defence Force Hospital, Riffa, Bahrain 3Senior Microbiology Lecturer, Royal College of Surgeons in IrelandMedical University of Bahrain, Behrain 4Lecturer in Epidemiology & Public Health Medicine, Royal college of Surgeons in Ireland, RCSI Bahrain *Corresponding author: Faqi MK, Orthopedic Resident, Department of Orthopedics, Royal Medical Services, Bahrain Defence Force Hospital, Riffa, Bahrain, E-mail: drmfaqi@gmail.com

Highlights

Despite the growing advancements of infection control and antibiotic therapy; the incidence of sepsis in developed countries has been persistently high reaching up to 30% of all admissions to intensive care units with a mortality rate of 62%, as reported in the SOAP study [1]
This study aims to determine the diagnostic accuracies of procalcitonin (PCT), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) as individual and combined predictors of bacterial sepsis, when compared to the gold standard microbiological cultures
Patients and methods: Forty-three patients were included in this study, provided they fulfilled the criteria established by ACCP/SCCM consensus conference for systemic inflammatory response syndrome (SIRS) and sepsis

Summary

Introduction

Despite the growing advancements of infection control and antibiotic therapy; the incidence of sepsis in developed countries has been persistently high reaching up to 30% of all admissions to intensive care units with a mortality rate of 62%, as reported in the SOAP study [1] Such unfavorable prognosis for septic patients appears to be multi-factorial; with delayed diagnosis and subsequent treatment being the most significant factor. One obstacle is the accurate differentiation between infectious sepsis and non-infectious causes of sepsis i.e. systemic inflammatory response syndrome (SIRS). This study aims to determine the diagnostic accuracies of procalcitonin (PCT), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) as individual and combined predictors of bacterial sepsis, when compared to the gold standard microbiological cultures. PCT is an indispensible biomarker for the early prediction of bacteremia, careful evaluation of patients’ clinical status and other laboratory markers are crucial

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