Abstract
Signal transducers and activators of transcription 6 (STAT6) arehighly expressed in various tumors and associated with tumorigenesis, immunosuppression, proliferation, metastasisand poor prognosis in human cancers. In response to IL-4/13, STAT6 is phosphorylated, dimerizesand triggers transcriptional regulation after recruitment of coactivators to transcriptosome, such as CBP/p300, SRC-1, PARP-14 and PSF. Post-translational modifications, including phosphorylation, ubiquitination, ADP-ribosylation and acetylation, have been explored for molecular mechanisms of STAT6 in tumor development and management. STAT6 has been developed as a specific biomarker for distinguishing and diagnosing tumor phenotypes, although it is observed to be frequently mutated in metastatic tumors. In this article, we focus mainly on the structural characteristics ofSTAT6 and its rolein tumor growth and progression.
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