The Roles of Phytoestrogens in Primate Ecology and Evolution

Abstract

Most primates depend heavily on plant foods; thus their chemical composition is key to understanding primate ecology and evolution. One class of plant compounds of strong current interest are phytoestrogens, which have the potential to alter fertility, fecundity, and survival. These plant compounds mimic the activity of vertebrate estrogens, resulting in altered physiology and behavior. Here, we review what is known about phytoestrogens from an ecological and evolutionary perspective. Much of what is known about the effects of phytoestrogens on the endocrine system comes from research on human foods, especially soybeans (Glycine max). Two opposing perspectives have resulted from this research: 1) phytoestrogens provide health benefits, such as cancer prevention, or 2) phytoestrogens act as endocrine disruptors and threaten reproductive health. Studies of wild primates have only recently begun examining the presence of estrogenic plants in the primate diet and the effects of their consumption. Evidence that a number of primate species eat plants containing phytoestrogens and research documenting behavioral and hormonal effects of estrogenic plant consumption for red colobus monkeys (Procolobus rufomitratus) augment captive and laboratory studies to suggest that these compounds promote differential survival and reproduction. Although much debate is currently taking place over the role of phytoestrogens and other endocrine disruptors in human health issues and in threatening biodiversity, we argue that an ecological and evolutionary approach is needed to reach appropriate conclusions.