Abstract
Objective To confirm the involvement of P38MAPK and caspase-8 in apoptosis and to reveal the signal transducation mechanism of apoptotic Bel-7402 cells. Methods Bel-7402 cells were treated with Fas-AD for 24h in the presence/absence of caspase-8 inhibitor Ac-IEFD-cho or SB203580. The expression of P38MAPK mRNA and caspase-8 mRNA was detected by RT-PCR. Results After Bel-7402 cells were treated with Fas-AD in the presence of the caspase-8 inhibitor Ac-IEFD-cho or P38MAPK inhibitor SB203580, the ex-pression of caspase-8 mRNA and P38MAPK mRNA significantly decreased. Conclusion P38MAPK and caspase-8 were involved in Fas-AD apoptotic pathway and regulated each other in mRNA level. Key words: P38MAPK; Caspase-8; Apoptosis
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