Abstract
Metastasis is an important factor in predicting the prognosis of the patients with cancers and contributes to high cancer-related mortality. It is well-known that the EMT processes are responsible for cancer progression and metastasis. Recent studies indicated that miRNAs played a functional role in the initiation and progression of human malignancies. MicroRNAs are small non-coding RNAs of about 22 nucleotides in length that can induce mRNA degradation or repress mRNA translation by binding to the 3′UTR of their target genes. Overwhelming reports indicated that miRNAs could regulate cancer invasion and metastasis via EMT-related and/or non-EMT-related mechanisms. In this review, we concentrate on the underlying mechanisms of miRNAs in regulating cancer progression and metastasis.
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