Abstract
Objective To explore the effect of leptin with neuropeptide Y(NPY), opioid melannocyte stimulating hormone primary cortical(POMC)neurons on type 2 diabetes mellitus when treated by gastric bypass operation. Methods Twenty adult SD rats were used to establish the model of type 2 diabetes mellitus, and divided into 2 groups: no operation group(NO,n= 10)and Roux-en-Y gastric bypass operation group (RYGB,n= 10),and another ten adult rats were used as the normal control group(NC,n= 10).The RYGB group were performed operation after the rat model of type 2 diabetes mellitus were successful established. The blood were separately collected to examine the blood sugar,cholesterol and triglyceride before and after the operation,we also monitored the consumption of food and water everyday.The hypothalamus tissues were collected at the 4th week after operation to examine the mRNA of NPY, POMC. Results At the 4th week after operation, the blood sugar,lipid and the consumption of food,water of RYGB group were nearly down to normal level.The level of leptin,NPY mRNA in hypothalamus were lower than NO group after operation,mean plasma leptin and NPY mRNA in hypothalamus levels were declined from(4.58±0.37)μg/L, 1.89±0.24 to(3.10±0.38)μg/L,0.95±0.19(P<0.01), respectively.The level of POMC mRNA in hypothalamus were significantly increased from 0.78±0.26 to 1.70±0.31(P<0.01). Conclusion It was demonstrated that the situation of type 2 diabetes mellitus can be controlled by Roux-en-Y gastric bypass operation. The leptin may regulate the energy metabolism of type 2 diabetes mellitus via NPY and POMC neurons signal. Our results suggest that the roles of leptin, NPY and POMC pathway may play an important part in the control of type 2 diabetes mellitus after Roux-en-Y gastric bypass operation. Key words: Leptin; Opioid melannocyte stimulating hormone primary cortical; Neuropeptide Y; Gastric bypass operation; Type 2 diabetes mellitus
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