The roles of GABAergic inhibitions in the striatum network in normal and dopamine-depleted states

Abstract

Event Abstract Back to Event The roles of GABAergic inhibitions in the striatum network in normal and dopamine-depleted states Man Y. Yim1*, Arvind Kumar2 and Ad Aertsen1, 2 1 Bernstein Center Freiburg, Germany 2 Albert-Ludwig University, Neurobiology and Biophysics, Faculty of Biology, Germany Medium spiny neurons (MSNs) are GABAergic neurons representing over 95% of the striatum neuron population. Based on the expression of dopamine receptors, MSNs can be divided into two subpopulations, D1- and D2-MSNs, which project to the basal ganglia (BG) output via the direct and indirect pathways, respectively. The duration of dopamine depletion has distinct effects on striatal activity. Acute dopamine depletion decreases D1- and increases D2-MSNs' activity. By contrast, chronic depletion increases the activity of both subpopulations. To understand the effects of dopamine-induced firing rate changes of D1- and D2-MSNs on the activity dynamics of striatum, we simulated a biologically realistic striatal network model. The model was characterized by weak feedback inhibition and strong feedforward inhibition from interneurons. In the normal state we assumed D1- and D2-MSNs had comparable firing rates. To simulate dopamine depleted states of the striatum, we systematically changed the firing rates of the D1- and D2-MSNs. We found that an increase in firing rate of one or both subpopulations enhanced the output correlation and might drive the network into oscillation, mediated by recurrent inhibition. The increased correlation in D2-MSNs may play a role in shaping oscillations in the BG, associated with the Parkinson's disease state. Supported by the German Federal Ministry of Education and Research (BMBF 01GQ0420 to BCCN Freiburg, BMBF GW0542 Cognition and BMBF 01GW0730 Impulse Control). Conference: EMBO workshop: Gaba Signalling and Brain Networks , Amsterdam, Netherlands, 30 Jun - 2 Jul, 2010. Presentation Type: Poster Presentation Topic: Posters Citation: Yim MY, Kumar A and Aertsen A (2010). The roles of GABAergic inhibitions in the striatum network in normal and dopamine-depleted states. Conference Abstract: EMBO workshop: Gaba Signalling and Brain Networks . doi: 10.3389/conf.fnins.2010.15.00027 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Jun 2010; Published Online: 25 Jun 2010. * Correspondence: Man Y Yim, Bernstein Center Freiburg, Freiburg, Germany, yim@bcf.uni-freiburg.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Man Y Yim Arvind Kumar Ad Aertsen Google Man Y Yim Arvind Kumar Ad Aertsen Google Scholar Man Y Yim Arvind Kumar Ad Aertsen PubMed Man Y Yim Arvind Kumar Ad Aertsen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.