Abstract
Aldosterone secretion rate and plasma renin activity have been measured before, during, and after total starvation in nine obese patients. The mean aldosterone secretion rate and the mean plasma renin activity rose significantly after 10 days of total starvation ( p <0.001 and p <0.02, respectively). When the patients were refed with carbohydrate, there was no further change in either of these parameters, although there was a significant fall in urinary sodium to levels below those predicted. It is concluded that the increase in aldosterone secretion and plasma renin activity that occurred during starvation may play a role in the reduction in urinary sodium that occurs in the later stages of starvation. However, the sudden and significant fall in urinary sodium that occurred when the patients were given carbohydrate must be due to factors other than the renin aldosterone system.
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