Abstract
10-Methacryloyloxydecyl dihydrogen phosphate (MDP) has been regarded as the most effective dentin-bonding monomer for more than 20 years. Although the dentin-bonding promoting effect of MDP has been well demonstrated, the mechanisms by which it benefits the stably of collagen within the adhesive–dentin hybrid layer are not currently fully understood. In the present study, we found that MDP preserves the hybrid layer through multiple modes of action. MDP forms a stable collagen-phosphate complex through strong hydrogen bonding with the collagen in dentin. Furthermore, it generates MDP-Ca salts that are deposited on the dentin collagen scaffold, protecting it from degradation. Moreover, both free MDP and the MDP-Ca salt inhibit matrix metallopeptidase directly, with the inhibitory effect of the calcium salt being significantly stronger than that of the free form. Based on the findings of this study, MDP-based adhesives preserve the collagen components within the hybrid layer by simultaneously improving the enzymatic resistance of collagen and inhibiting MMP activity, both of which contribute to the longevity of dentin–resin bonding.
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